Isopropyl isocyanate → N-{2-[4-amino-2-butyl-7-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl]ethyl}-N'-(1-methylethyl)urea

HRID 9440

反応式

HRID 9440 の反応式
[CH:1]([N:4]=[C:5]=[O:6])([CH3:3])[CH3:2].[NH2:7][CH2:8][CH2:9][N:10]1[C:22]2[C:21]3[CH:20]=[CH:19][C:18]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)=[CH:17][C:16]=3[N:15]=[C:14]([NH2:29])[C:13]=2[N:12]=[C:11]1[CH2:30][CH2:31][CH2:32][CH3:33]>C(Cl)(Cl)Cl>[NH2:29][C:14]1[C:13]2[N:12]=[C:11]([CH2:30][CH2:31][CH2:32][CH3:33])[N:10]([CH2:9][CH2:8][NH:7][C:5]([NH:4][CH:1]([CH3:3])[CH3:2])=[O:6])[C:22]=2[C:21]2[CH:20]=[CH:19][C:18]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[CH:17][C:16]=2[N:15]=1

参加物

4

反応物 2

HCID 61277Isopropyl isocyanateHCID 219844221-(2-Aminoethyl)-2-butyl-7-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine

生成物 1

HCID 21984352N-{2-[4-amino-2-butyl-7-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl]ethyl}-N'-(1-methylethyl)urea収率 47.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Isopropyl isocyanate (0.29 mL, 3.1 mmol) was added slowly to a suspension of 1-(2-aminoethyl)-2-butyl-7-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine (1.13 g, 3.1 mmol) in chloroform (113 mL). A precipitate formed within 15 minutes, was isolated by filtration, and was dried overnight in an oven to provide 0.66 g of N-{2-[4-amino-2-butyl-7-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl]ethyl}-N′-(1-methylethyl)urea as a white solid, mp 240–241° C.

後処理

  1. customA precipitate formed within 15 minutes
  2. customwas isolated by filtration
  3. customwas dried overnight in an oven

出典と根拠

ORDレコード
ord-3db7633c7790473bbf510fa12aa014cc
出典データセット
uspto-grants-2006_08
特許番号
US07091214B2

関連ノート

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