Trifluoromethylsulfonamide → 3,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide

HRID 947

反応式

HRID 947 の反応式
[F:1][C:2]([F:8])([F:7])[S:3]([NH2:6])(=[O:5])=[O:4].[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12](Cl)=[O:13]>[OH-].[Na+]>[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12]([NH:6][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:5])=[O:4])=[O:13]

参加物

4

反応物 2

HCID 79001TrifluoromethylsulfonamideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

生成物 1

HCID 153350263,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide収率 16.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To an ice-cooled solution of trifluoromethanesulfonamide (2.75 g, 18.4 mmol) in 7.4 mL of 2.5 N sodium hydroxide was added 3,4,4-trifluoro-3-butenoyl chloride (2.93 g, 18.5 mmol) with stirring in 2 min. The mixture was stirred in cold for 30 min and the white precipitate formed was filtered, washed with cold water (10 mL) and dried to give 0.82 g (16%) of the desired product as a white solid. m.p. 115°-120° C.

後処理

  1. stirringThe mixture was stirred in cold for 30 min
  2. customthe white precipitate formed
  3. filtrationwas filtered
  4. washwashed with cold water (10 mL)
  5. customdried

出典と根拠

ORDレコード
ord-e1a0dc1a113c454bac338b6a5d18d9a1
出典データセット
uspto-grants-1998_03
特許番号
US05723470

関連ノート

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