Trifluoromethylsulfonamide → 3,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide
反応式
[F:1][C:2]([F:8])([F:7])[S:3]([NH2:6])(=[O:5])=[O:4].[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12](Cl)=[O:13]>[OH-].[Na+]>[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12]([NH:6][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:5])=[O:4])=[O:13]参加物
4
実験手順
To an ice-cooled solution of trifluoromethanesulfonamide (2.75 g, 18.4 mmol) in 7.4 mL of 2.5 N sodium hydroxide was added 3,4,4-trifluoro-3-butenoyl chloride (2.93 g, 18.5 mmol) with stirring in 2 min. The mixture was stirred in cold for 30 min and the white precipitate formed was filtered, washed with cold water (10 mL) and dried to give 0.82 g (16%) of the desired product as a white solid. m.p. 115°-120° C.
後処理
- stirringThe mixture was stirred in cold for 30 min
- customthe white precipitate formed
- filtrationwas filtered
- washwashed with cold water (10 mL)
- customdried
出典と根拠
- ORDレコード
- ord-e1a0dc1a113c454bac338b6a5d18d9a1
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723470
反応ノート
読み込み中…