5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione → 5-Bromoquinolin-4-ol

HRID 9474

反応式

[Br:1][C:2]1[CH:3]=[C:4]([NH:8][CH:9]=[C:10]2[C:15](=[O:16])OC(C)(C)OC2=O)[CH:5]=[CH:6][CH:7]=1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:15]([OH:16])=[CH:10][CH:9]=[N:8]2)=[CH:6][CH:7]=1.[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[C:15]([OH:16])=[CH:10][CH:9]=[N:8]2

参加物

実験手順

5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (32.6 g, 0.100 mol) was heated at 250° C. in DOWTHERM A heat transfer fluid for one hour, and then the reaction was allowed to cool to ambient temperature. A precipitate formed upon cooling and was isolated by filtration and washed with diethyl ether to provide 7-bromoquinolin-4-ol and 5-bromoquinolin-4-ol in a 2:1 ratio.

後処理

temperatureheat transfer fluid for one hour
customA precipitate formed
temperatureupon cooling
customwas isolated by filtration
washwashed with diethyl ether

出典と根拠

ORDレコード: ord-b1f865ef25a04e39839832f0be237929
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07091214B2

反応式

参加物

反応物 1

生成物 2

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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