Bromomethylcyclopropane → 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-cyclopropylmethoxyethoxy) methyl)piperidine Hydrochloride

HRID 962472

反応式

HRID 962472 の反応式
[ClH:1].[C:2]1([C:8]2([CH2:14][O:15][CH:16]([C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=3)[CH2:17][OH:18])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:33]1([CH2:36]Br)[CH2:35][CH2:34]1>>[ClH:1].[C:2]1([C:8]2([CH2:14][O:15][CH:16]([C:19]3[CH:24]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:22]=[C:21]([C:29]([F:32])([F:30])[F:31])[CH:20]=3)[CH2:17][O:18][CH2:36][CH:33]3[CH2:35][CH2:34]3)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 81503BromomethylcyclopropaneHCID 190847004-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy) methyl)piperidine Hydrochloride

生成物 1

HCID 883225484-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-cyclopropylmethoxyethoxy) methyl)piperidine Hydrochloride

実験手順

This was prepared in a similar manner to Example 2 using the compound of Example 1 (d) and cyclopropyl methyl bromide. 1H NMR (360MHz, d6 -DMSO) δ 7.91 (1H, s), 7.66 (2H, s), 7.35-7.19 (5H, m), 4.58 (1H, t, J=4.7 Hz), 3.50-3.06 (6H, m), 2.76-2.61 (2H, m), 2.33-2.17 (2H, m), 2.08-1.94 (2H, m), 0.84-0.77 (1H, m), 0.36-0.30 (2H, m), 0.01-0.06 (2H, m). MS (Cl+) 502 (M+H)+.

出典と根拠

ORDレコード
ord-cdd1545710d34ef39bfb95469cf1ec01
出典データセット
uspto-grants-1998_06
特許番号
US05760018

関連ノート

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