Ethyl 3-[4-(benzyloxy)-2-methylphenyl]prop-2-enoate → Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate

HRID 9629

反応式

HRID 9629 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:11]([CH3:22])[CH:10]=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:11]([CH3:22])[CH:10]=1

参加物

4

反応物 1

HCID 67072140Ethyl 3-[4-(benzyloxy)-2-methylphenyl]prop-2-enoate2 回

生成物 1

HCID 21986481Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒2 回

実験手順

A solution of ethyl 3-[4-(benzyloxy)-2-methylphenyl]prop-2-enoate (intermediate 11, 1.054 g) in ethanol (50 ml) was added to a suspension of palladium hydroxide on carbon (0.15 g) in ethanol (5 ml) under nitrogen gas. The resulting suspension was then stirred under a hydrogen atmosphere for 3 hours. The mixture was filtered through Harborlite filter aid and the pad washed with more ethanol. The combined filtrates were evaporated in vacuo to give the title compound as a clear oil.

後処理

  1. filtrationThe mixture was filtered through Harborlite
  2. filtrationfilter aid
  3. washthe pad washed with more ethanol
  4. customThe combined filtrates were evaporated in vacuo

出典と根拠

ORDレコード
ord-6d306e3fc497442fa8890ead9fcc7c78
出典データセット
uspto-grants-2006_08
特許番号
US07091237B2

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