Sodium hydride → (3RS)-1-(2-acetylthiophen-3-yl)methyl-3-tert-butoxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

反応式

[H-].[Na+].[C:3]([O:7][C:8]([NH:10][CH:11]1[N:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=2[NH:13][C:12]1=[O:29])=[O:9])([CH3:6])([CH3:5])[CH3:4].[C:30]([C:33]1[S:34][CH:35]=[CH:36][C:37]=1[CH2:38]Br)(=[O:32])[CH3:31]>CN(C)C=O>[C:30]([C:33]1[S:34][CH:35]=[CH:36][C:37]=1[CH2:38][N:13]1[C:14]2[CH:28]=[CH:27][CH:26]=[CH:25][C:15]=2[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])=[N:17][CH:11]([NH:10][C:8]([O:7][C:3]([CH3:6])([CH3:4])[CH3:5])=[O:9])[C:12]1=[O:29])(=[O:32])[CH3:31]