5-(3-nitrophenyl)tetrazole → HCID 178507542、化合物

HRID 963508

反応式

HRID 963508 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[NH:14][N:13]=[N:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[NH:14][N:13]=[N:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 2851295-(3-nitrophenyl)tetrazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 178507542HCID 178507542、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

5-(3-Nitrophenyl)-1H-tetrazole (4.41 g) was hydrogenated in ethanol (50 ml) over 10% palladium on carbon (0.4 g) under 3 atmospheric pressure of hydrogen at ambient temperature. The reaction mixture was filtered through Celite® (Johns Manville) and washed with ethanol. The filtrate and the washings were combined and evaporated to give 5-(3-aminophenyl)-1H-tetrazole as a crystalline powder, which was triturated in diisopropyl ether and collected by filtration to afford the desired product as a white powder (3.19 g, 85.8%). This was used in a following reaction without further purification.

後処理

  1. filtrationThe reaction mixture was filtered through Celite® (Johns Manville)
  2. washwashed with ethanol
  3. customevaporated

出典と根拠

ORDレコード
ord-8378aeccf8f84e9b87afc882ab018903
出典データセット
uspto-grants-1998_06
特許番号
US05763437

関連ノート

読み込み中…