Pyridine → Nalpha-Cinnamoyl-L-lysine

関与物質

役割	名称	HCID	仕込み量
反応物	Pyridine	HCID 1049	—
反応物	3-Phenylprop-2-enoyl chloride	HCID 66023	—
反応物	(2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid	HCID 2733283	—
溶媒	Chloroform	HCID 6212	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	Nalpha-Cinnamoyl-L-lysine	HCID 53746252	—

反応手順

Nε-t-Butoxycarbonyl-L-lysine (2.58 g) was dissolved in 50 ml of dimethylformamide, and 30 ml of anhydrous pyridine was added to the solution. To the mixture was added a solution of cinnamoyl chloride in chloroform (1.665 g/20 ml) was added, and the reaction was carried out at 40° C. The reaction mixture was concentrated to dryness under reduced pressure, the residue was dissolved in 3.6N HCl/dioxane (33 ml) and, after 4 hours of standing, the solution was concentrated under reduced pressure to give the desired compound (2.43 g; hereinafter referred to as compound B).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US05763504
出典データセット	uspto-grants-1998_06
ORD ID	ord-6833cb4d0c1e4459a7473e26f7b6418c
出典メモ	uspto-grants-1998_06