反应详情

Nε-t-Butoxycarbonyl-L-lysine (2.58 g) was dissolved in 50 ml of dimethylformamide, and 30 ml of anhydrous pyridine was added to the solution. To the mixture was added a solution of cinnamoyl chloride in chloroform (1.665 g/20 ml) was added, and the reaction was carried out at 40° C. The reaction mixture was concentrated to dryness under reduced pressure, the residue was dissolved in 3.6N HCl/dioxane (33 ml) and, after 4 hours of standing, the solution was concentrated under reduced pressure to give the desired compound (2.43 g; hereinafter referred to as compound B).

1. additionwas added
2. customwas carried out at 40° C
3. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
4. dissolutionthe residue was dissolved in 3.6N HCl/dioxane (33 ml) and, after 4 hours
5. concentrationthe solution was concentrated under reduced pressure