Sodium Azide → 9-Azidononanoic acid

HRID 963962ノート

反応式

HRID 963962 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[N-:13]=[N+:14]=[N-:15].[Na+]>CN(C=O)C>[N:13]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[N+:14]=[N-:15]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 5482219-Bromononanoic Acid

生成物 1

HCID 152305499-Azidononanoic acid収率 84%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

9-Bromo-nonanoic acid (3.82 g, 17 mmol) was dissolved in DMF (30 mL) and sodium azide (1.11 g, 17 mmol) was added. The solution was heated to 80° C. and stirred overnight. The reaction was poured onto ice and extracted with DCM (3×200 mL). The combined extracts were washed with water (3×200 mL), brine (200 mL), and dried over MgSO4. The solvent was removed in vacuo to give a clear oil 2.83 g (84% yield);

後処理

  1. additionThe reaction was poured onto ice
  2. extractionextracted with DCM (3×200 mL)
  3. washThe combined extracts were washed with water (3×200 mL), brine (200 mL)
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-aaec078de2db4d3c861dca7845a41ca2
出典データセット
uspto-grants-1998_06
特許番号
US05767088

反応ノート

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