1,1-Diphenylbutane-1,4-diol → 4,4-Diphenylbutan-1-ol

HRID 963978ノート

反応式

HRID 963978 の反応式
[C:1]1([C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(O)[CH2:8][CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:13]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][CH2:10][OH:11])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

4

反応物 1

HCID 966791,1-Diphenylbutane-1,4-diol

生成物 1

HCID 925194,4-Diphenylbutan-1-ol収率 91%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1,1-Diphenyl-1,4-butanediol (26.62 g, 0.110 mol) was dissolved in MeOH and shaken with 20% Pd/C (1.50 g) on a Parr apparatus under an H2 atmosphere (50 psi) for 17 hours. The MeOH was removed in vacuo, and the residue chromatographed on silica gel eluting with 35% EtOAc/Hexanes gave 22.53 g (91%) of desired product.

後処理

  1. customThe MeOH was removed in vacuo
  2. customthe residue chromatographed on silica gel eluting with 35% EtOAc/Hexanes

出典と根拠

ORDレコード
ord-bddfb8fb4083420fb48abe2792373864
出典データセット
uspto-grants-1998_06
特許番号
US05767129

反応ノート

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