Hydrochloric Acid → 8-Methoxy-1,4-benzodioxan-2-ylmethyl toluene-4-sulphonate

反応式

[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[C:19]2[O:20][CH:21]([CH2:24][OH:25])[CH2:22][O:23][C:18]=2[CH:17]=[CH:16][CH:15]=1.Cl>N1C=CC=CC=1>[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([O:25][CH2:24][CH:21]2[O:20][C:19]3[C:14]([O:13][CH3:12])=[CH:15][CH:16]=[CH:17][C:18]=3[O:23][CH2:22]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1

参加物

実験手順

A solution of toluene-4-sulphonyl chloride (5.84 g) in pyridine (10 ml) was added dropwise at 10°-15° C. to a solution of 1-(8-methoxy-1,4-benzodioxan-2-yl)methanol (5.0 g) in pyridine (30 ml) and the mixture was stirred at ambient temperature for 20 hours. The mixture was poured onto an excess of ice and dilute hydrochloric acid. The resulting solid was collected by filtration, washed with water and dried in vacuo to yield 8-methoxy-1,4-benzodioxan-2-ylmethyl toluene-4-sulphonate as a white solid (6.61 g), m.p. 66°-68° C.