4-Carbamoyl-1-phenylpyridinium chloride → 1-Phenylpiperidine-4-carboxamide

HRID 963998ノート

反応式

HRID 963998 の反応式
[Cl-].[C:2]([C:5]1[CH:10]=[CH:9][N+:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])[NH2:3]>[Pd].C(O)C>[C:11]1([N:8]2[CH2:9][CH2:10][CH:5]([C:2]([NH2:3])=[O:4])[CH2:6][CH2:7]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 107048844-Carbamoyl-1-phenylpyridinium chloride

生成物 1

HCID 105843391-Phenylpiperidine-4-carboxamide収率 52.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 4-carbamoyl-1-phenylpyridinium chloride (13 g), 10% palladium-on-carbon catalyst (260 mg) and ethanol (250 ml) was hydrogenated at ambient temperature and pressure for 2 days. The solution was filtered (Celite) and the filtrate was concentrated to approximately 50 ml. This solution was cooled and the solid precipitate collected by filtration to give 1-phenylpiperidine-4-carboxamide (5.99 g).

後処理

  1. customwas hydrogenated at ambient temperature
  2. filtrationThe solution was filtered (Celite)
  3. concentrationthe filtrate was concentrated to approximately 50 ml
  4. temperatureThis solution was cooled
  5. filtrationthe solid precipitate collected by filtration

出典と根拠

ORDレコード
ord-a11b4d6683ae48778c67323737e82d03
出典データセット
uspto-grants-1998_06
特許番号
US05767116

反応ノート

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