3-Amino-1-propanol → HCID 19079352、化合物

HRID 964048ノート

反応式

HRID 964048 の反応式
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].Cl[CH2:10][CH2:11][CH2:12][NH:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH:20]=1.OCCCN.ClCC1C=NC=C(C2C=CC(F)=CC=2)C=1.P(Cl)(Cl)Cl>C(#N)C>[O:7]([CH2:10][CH2:11][CH2:12][NH:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([C:21]2[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=2)[CH:20]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

7

反応物 5

HCID 90863-Amino-1-propanolHCID 24387Phosphorus trichlorideHCID 4445035Phenolate SodiumHCID 109330253-(Chloromethyl)-5-(4-fluorophenyl)pyridineHCID 19079504N-3-chloropropyl-N-[5-(4-fluorophenyl)-3-pyridylmethyl]-amine

生成物 1

HCID 19079352HCID 19079352、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Analogously to Example 7 a solution of 2.3 g sodium phenolate and 2.5 g N-3-chloropropyl-N-[5-(4-fluorophenyl)-3-pyridylmethyl]-amine [obtainable by reaction of 3-hydroxypropylamine with 3-chloromethyl-5-(4-fluorophenyl)-pyridine and subsequent transformation of the product to the 3-chloropropyl-compound by reaction with PCl3 ] in 200 ml of acetonitrile is stirred for 5 hours at room temperature and worked up in a conventional manner to give N-(3-phenoxy-propyl)-N-[5-(4-fluorophenyl)-3-pyridyl-methyl]-amine. Stirring with Q5 equivalents of oxalic acid in 100 ml ethanol/water mixture gives the oxalate-hemihydrate, m.p. 217°.

出典と根拠

ORDレコード
ord-0f597c166fd4421c9ec10b4918b1bd12
出典データセット
uspto-grants-1998_06
特許番号
US05767132

反応ノート

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