Diketene → HCID 23004067、化合物

HRID 964229ノート

反応式

HRID 964229 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=2)[CH2:12]1>C1COCC1>[CH3:22][O:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][C:15]=1[O:23][CH3:24])[CH2:12][N:11]([CH2:10][CH2:9][CH2:8][NH:7][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:20][CH2:19]2

参加物

4

反応物 2

HCID 12661DiketeneHCID 230040563,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanamine

生成物 1

HCID 23004067HCID 23004067、化合物収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Diketene (1.41 mL, 18.3 mmol, 1.50 equiv) was added at 0° C. to a stirred solution of 2-(3-aminopropyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (3.05 g, 12.2 mmol, 1.00 equiv) in anhydrous THF (30 mL) under argon, and stirring was continued at room temperature for 1.5 hours. The mixture was concentrated and the residual oil washed with hexane (2×100 mL) to give 4.07 g (100%) of brown oil, which was characterized spectroscopically and used for the next reaction without purification.

後処理

  1. concentrationThe mixture was concentrated
  2. washthe residual oil washed with hexane (2×100 mL)

出典と根拠

ORDレコード
ord-5f45d35e1c4f49e3b48b42e538e52c13
出典データセット
uspto-grants-1998_06
特許番号
US05767131

反応ノート

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