Butylamine → n4-Butyl-6-chloropyrimidine-2,4-diamine
反応式
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[CH2:10]([NH2:14])[CH2:11][CH2:12][CH3:13]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([NH:14][CH2:10][CH2:11][CH2:12][CH3:13])[CH:5]=[C:6]([Cl:8])[N:7]=1参加物
4
実験手順
10 g of 2-amino-4,6-dichloropyrimidine are suspended in 100 ml of ethanol. 11.15 g of butylamine are added. The reaction mixture is refluxed for 2 hours and then evaporated to dryness. The residue is taken up in 100 ml of water. After 1 hour's stirring the precipitate is filtered off on sintered glass and is then recrystallized from 80 ml of 6/4 water/acetonitrile. 8.75 g of 2-amino-4-butylamino-6-chloropyrimidine are obtained.
後処理
- temperatureThe reaction mixture is refluxed for 2 hours
- customevaporated to dryness
- filtrationis filtered off on sintered glass
- customis then recrystallized from 80 ml of 6/4 water/acetonitrile
出典と根拠
- ORDレコード
- ord-eab0454af4b841da9a5e016277412805
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05772990
反応ノート
読み込み中…