Methyl chloroformate → Methyl 5-methylthiophene-3-carboxylate
反応式
Br[C:2]1[CH:6]=[C:5]([CH3:7])[S:4][CH:3]=1.Cl[C:9]([O:11][CH3:12])=[O:10]>>[CH3:7][C:5]1[S:4][CH:3]=[C:2]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=1参加物
3
実験手順
Alternatively, initial lithiation of 3-bromo-5-methylthiophene followed by capture with methyl chloroformate gives methyl 5-methylthiophene-3-carboxylate. Free-radical bromination of the methyl group followed by treatment with an alkali azide, subsequent reduction and hydrolysis provides 5-(aminomethyl)thiophene-3-carboxylic acid (VI). ##STR38##
出典と根拠
- ORDレコード
- ord-3c5661c1ca514df4b87078e618ecbe2d
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05773411
反応ノート
読み込み中…