Hydrogen Bromide → HCID 135829331、化合物

HRID 964995ノート

反応式

HRID 964995 の反応式
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([Cl:13])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+].[BrH:19]>>[Cl:13][C:7]1[C:6]2[C:11](=[CH:12][C:3]([OH:2])=[CH:4][CH:5]=2)[N:10]=[C:9]([Br:19])[CH:8]=1

参加物

4

反応物 3

HCID 260Hydrogen BromideHCID 516892Sodium BicarbonateHCID 106078294-Chloro-7-methoxyquinoline

生成物 1

HCID 135829331HCID 135829331、化合物

実験手順

7-Methoxy-4-chloroquinoline(13 g, 67 mmol) was refluxed for 24 hours with 47% hydrobromic acid (30 ml). After allowing to cool, aqueous solution of saturated sodium bicarbonate was added for neutralization and the resulting crystals were filtered. The obtained crystals were washed with water, sufficiently dried and recrystallized from ethanol to obtain 9 g of 4-chloro(bromo)-7-hydroxyquinoline [a mixture of 4-chloro-7-hydroxyquinoline and 4-bromo-7-hydroxy-quinoline (7 : 3)]. This mixture was used without further purification as the starting material in a next reaction.

後処理

  1. temperatureto cool
  2. filtrationthe resulting crystals were filtered
  3. washThe obtained crystals were washed with water
  4. customsufficiently dried
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-d8bd8009cdbb41e0951675139e9f6e04
出典データセット
uspto-grants-1998_06
特許番号
US05773449

反応ノート

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