Sodium borohydride → (4-Chloroquinolin-7-yl)methanol

HRID 965000ノート

反応式

HRID 965000 の反応式
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:15])=[CH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1)=O.[BH4-].[Na+]>CO>[OH:2][CH2:3][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:15])=[CH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 21708520Methyl 4-chloroquinoline-7-carboxylate

生成物 1

HCID 22054610(4-Chloroquinolin-7-yl)methanol収率 30.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

7-Methoxycarbonyl-4-chloroquinoline(3.75 g, 0.017 mol) was dissolved in methanol (200 ml), added under ice-cooling with sodium borohydride (12.9 g, 0.34 mol) and stirred for an hour. The reaction mixture was poured into ice water. The resulting precipitates were collected by filtration, dried over phosphorus pentoxide and recrystallized from chloroform (20 ml) to obtain 1.0 g (30%) of 7-hydroxymethyl-4-chloroquinoline.

後処理

  1. additionadded under ice-
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. dry with materialdried over phosphorus pentoxide
  5. customrecrystallized from chloroform (20 ml)

出典と根拠

ORDレコード
ord-46de3671617c45bd83848ffcb82be690
出典データセット
uspto-grants-1998_06
特許番号
US05773449

反応ノート

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