1,1',1''-(Chlorosilylidyne)tris(benzene) → HCID 178420877、化合物
反応式
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.C1([Si](C2C=CC=CC=2)(C2C=CC=CC=2)Cl)C=CC=CC=1>N1C=CC=CC=1>[N:10]1[CH:2]=[C:3]2[C:7]([NH:6][CH:5]=[N:4]2)=[N:8][CH:9]=1参加物
4
実験手順
14.3 g of 6-chloro-9-β-D-ribofuranosyl-9H-purine and 15 g of triphenylchlorosilane were dissolved in 500 ml of pyridine and stirred for one hour at room temperature. Pyridine was distilled away and the residue was dissolved in benzene. The benzene layer was washed with 1N HCl and brine, and then dried over sodium sulfate anhydride. The solvent was distilled off and the residue was recrystallized from a mixture of hexane and ethyl acetate to give 21.5 g of 6-chloro--9-15-O-triphenylsilyl-β-D-ribofuranosyl)-9H-purine.
後処理
- distillationPyridine was distilled away
- dissolutionthe residue was dissolved in benzene
- washThe benzene layer was washed with 1N HCl and brine
- dry with materialdried over sodium sulfate anhydride
- distillationThe solvent was distilled off
- customthe residue was recrystallized from a mixture of hexane and ethyl acetate
出典と根拠
- ORDレコード
- ord-7506b4f9e7e6415f8b38ff6c549793c6
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05773603
反応ノート
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