Chlorine → 1,2-Benzisothiazol-3(2H)-one

HRID 965405

反応式

HRID 965405 の反応式
C[S:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH:5]=[N:6]O.ClCl.S(Cl)(Cl)(=O)=[O:15]>ClC1C=CC=CC=1>[S:2]1[C:3]2[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=2[C:5](=[O:15])[NH:6]1

参加物

5

反応物 3

HCID 24526ChlorineHCID 24648Sulfuryl chlorideHCID 7867572-(Methylthio)benzaldehyde oxime2 回

生成物 1

HCID 175201,2-Benzisothiazol-3(2H)-one収率 91.1%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

From the monochlorobenzene layer obtained by the same procedures as in Example 1, 2-(methylthio)benzaldehyde oxime was isolated in the same manner as in Example 2. 39.7 g of the oxime isolated was dissolved in 150 g of monochlorobenzene. Then, the oxime was cyclized in the same manner as in Example 1 except that chlorine was changed to 35.3 g (0.26 mol) of sulfuryl chloride. As a result, 32.7 g of 1,2-benzisothiazol-3-one was obtained. The yield against 2-(methylthio)benzaldehyde oxime was 91%.

出典と根拠

ORDレコード
ord-5487ba3d2dad411c91c81364658c44ca
出典データセット
uspto-grants-1998_06
特許番号
US05773626

関連ノート

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