Pentylamine → 2-Chloro-N-pentyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-4-amine

反応式

[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=1.[CH2:12]([NH2:17])[CH2:13][CH2:14][CH2:15][CH3:16].[Cl-].[NH4+]>>[Cl:1][C:2]1[N:3]=[C:4]([NH:17][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:5]2[CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=1

参加物

反応物 3

HCID 8060Pentylamine

HCID 25517Ammonium Chloride

HCID 2313312,4-dichloro-5H,6H,7H-cyclopenta(d)pyrimidine

生成物 1

HCID 223132482-Chloro-N-pentyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-4-amine収率 65%

実験手順

A mixture of 2,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine (410 mg) and pentylamine (1 ml) were stirred at room temperature for 8 hours. The reaction mixture was poured into an aqueous ammonium chloride solution and the solution was extracted with chloroform. The organic layer was washed with saturated brine, dried over sodium sulfate and concentrated in vacuo to give the object compound (296 mg, 65%).