Lithium Hydroxide → 5-Amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylic acid

HRID 965790ノート

反応式

HRID 965790 の反応式
[NH2:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([C:11]([O:13]CC)=[O:12])=[CH:4][C:3]=1[Cl:16].[OH-].[Li+]>CO>[NH2:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([C:11]([OH:13])=[O:12])=[CH:4][C:3]=1[Cl:16]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 12088090Ethyl 5-amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylate

生成物 1

HCID 120880915-Amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylic acid収率 86%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a stirred solution of ethyl 5-amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylate (Example 1, METHOD A, Step 3, 217 mg, 0.91 mmol) in methanol (5 mL) was added 1N aqueous lithium hydroxide (500 μL) and the mixture was stirred overnight at room temperature. The solvent was removed in vacuo and acidified with 1N hydrochloric acid. The resultant precipitate was collected by filtration to give 165 mg (86%) of the title compound as a white solid.

後処理

  1. customThe solvent was removed in vacuo
  2. filtrationThe resultant precipitate was collected by filtration

出典と根拠

ORDレコード
ord-6f4e84dcb75f4f718cab610a33144212
出典データセット
uspto-grants-2005_10
特許番号
US06951867B2

反応ノート

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