Hydrochloric Acid → 4-Bromo-2-chloro-N-(2-oxoethyl)benzamide
反応式
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][CH:10](OCC)[O:11]CC)=[O:7])=[C:4]([Cl:19])[CH:3]=1.Cl.O>C1COCC1>[Br:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][CH:10]=[O:11])=[O:7])=[C:4]([Cl:19])[CH:3]=1参加物
5
実験手順
To a solution of 4-bromo-2-chloro-N-(2,2-diethoxyethyl)benzamide (14.88 g, 42.44 mmol) in THF (50 mL) was added 2N HCl (50 mL) at room temperature. After 24 hours, water (100 mL) was added to the mixture, then the mixture was extracted with ethyl acetate (100 mL×2), the organic layer was washed with water (50 mL), dried over MgSO4. Removal of the solvent, gave a title compound (6.98 g, 60% yield).
後処理
- extractionthe mixture was extracted with ethyl acetate (100 mL×2)
- washthe organic layer was washed with water (50 mL)
- dry with materialdried over MgSO4
- customRemoval of the solvent
出典と根拠
- ORDレコード
- ord-793cb3f9d5cf4a07b5b4fefa5aa49e44
- 出典データセット
- uspto-grants-2005_10
- 特許番号
- US06951876B2
反応ノート
読み込み中…