Hydrochloric Acid → HCID 21986508、化合物

HRID 9660ノート

反応式

HRID 9660 の反応式
[Br:1][C:2]1[S:6][C:5]([C:7](=[O:9])C)=[C:4]([CH3:10])[CH:3]=1.[BH4-].[Na+].Cl>C(O)C>[Br:1][C:2]1[S:6][C:5]([CH2:7][OH:9])=[C:4]([CH3:10])[CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 21986456HCID 21986456、化合物2 回

生成物 1

HCID 21986508HCID 21986508、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

A mixture of 1-(5-bromo-3-methylthien-2-yl)ethanone (intermediate 82, 5.13 g) in ethanol (50 ml) was treated with sodium borohydride (0.947 g). The reaction was stirred at 0° C. for 60 minutes and warmed to room temp for 30 minutes. 2M Aqueous hydrochloric acid was added and the reaction mixture was extracted with ethyl acetate twice. The organic solutions were combined and dried with brine and over magnesium sulfate. The title compound was isolated after removal of the desiccant and evaporation of the solvent.

後処理

  1. temperaturewarmed to room temp for 30 minutes
  2. extractionthe reaction mixture was extracted with ethyl acetate twice
  3. dry with materialdried with brine and over magnesium sulfate

出典と根拠

ORDレコード
ord-52cc4b26200a4c778030d3f61d23cf78
出典データセット
uspto-grants-2006_08
特許番号
US07091237B2

反応ノート

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