Water → Mesitylacetic acid

HRID 966099

反応式

HRID 966099 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[CH2:10][C:11]#N.S(=O)(=O)(O)[OH:14].[OH2:18]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[CH2:10][C:11]([OH:14])=[O:18]

参加物

4

反応物 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 5206982,4,6-Trimethylphenylacetonitrile

生成物 1

HCID 78123Mesitylacetic acid

反応条件

温度
50 °C

実験手順

155 g (2,4,6-trimethylphenyl)acetonitrile are added to a solution of 1.1 L of water and 915 mL of concentrated sulfuric acid heated to 50° C. The mixture is refluxed for 6 hours with stirring. Then the reaction mixture is poured onto 3 kg of ice. The solid is suction filtered and washed with water. Yield: 131 g (86%); melting point: 163° C.-166° C.

後処理

  1. temperatureThe mixture is refluxed for 6 hours
  2. filtrationfiltered
  3. washwashed with water

出典と根拠

ORDレコード
ord-61a96cad4476460eaf917227b47a8666
出典データセット
uspto-grants-2005_10
特許番号
US06951888B2

関連ノート

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