HCID 69733344、化合物 → HCID 10067963、化合物

HRID 966104ノート

反応式

HRID 966104 の反応式
Cl.[OH:2][C:3]1[C:4]([O:27][CH3:28])=[C:5]([C:10](=[O:26])[CH2:11][NH:12][C:13]([CH3:25])([CH3:24])[CH2:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])[CH:6]=[CH:7][C:8]=1[OH:9]>CO.[Pt](=O)=O>[CH3:25][C:13]([NH:12][CH2:11][CH:10]([C:5]1[C:4]([O:27][CH3:28])=[C:3]([OH:2])[C:8]([OH:9])=[CH:7][CH:6]=1)[OH:26])([CH3:24])[CH2:14][C:15]1[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=1[CH3:23]

参加物

4

反応物 1

HCID 69733344HCID 69733344、化合物

生成物 1

HCID 10067963HCID 10067963、化合物

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

9 g of 1-(3,4-dihydroxy-2-methoxyphenyl)-2-[1,1-dimethyl-2-(2,4,6-trimethylphenyl)-ethylamino]ethanone hydrochloride is hydrogenated with 0.4 g of platinum(IV) oxide in 125 mL of methanol. The catalyst is filtered off and the solvent is distilled off under reduced pressure. The residue is dissolved in 50 mL of ethyl acetate and the precipitated crystals are suction filtered and washed with diethyl ether and ethyl acetate. Yield: 6 g (67%, hydrochloride); melting point: 98° C.-105° C.

後処理

  1. filtrationThe catalyst is filtered off
  2. distillationthe solvent is distilled off under reduced pressure
  3. dissolutionThe residue is dissolved in 50 mL of ethyl acetate
  4. filtrationfiltered
  5. washwashed with diethyl ether and ethyl acetate

出典と根拠

ORDレコード
ord-74c2ff880a7240749afd9141298e556e
出典データセット
uspto-grants-2005_10
特許番号
US06951888B2

反応ノート

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