Hydrazine → 2-Pyrazinepropanamine
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][N:10]1C(=O)C2=CC=CC=C2C1=O.NN>C(Cl)(Cl)Cl>[NH2:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1参加物
4
実験手順
N-[3-(2-Pyrazinyl)propyl]phthalimide (521 mg, 1.95 mmol) was dissolved in chloroform (15 mL) followed by addition of anhydrous hydrazine (1.5 mL), and then the mixture was stirred at room temperature for 20 hours. The resulting precipitate was removed by filtration, and the filtrate was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and 2-(3-aminopropyl)pyrazine (240 mg; yield 90%) was thus obtained.
後処理
- customThe resulting precipitate was removed by filtration
- washthe filtrate was washed with water
- dry with materialdried over anhydrous sodium sulfate
出典と根拠
- ORDレコード
- ord-9ce6b49e5a90408284179b193747c0f3
- 出典データセット
- uspto-grants-2005_10
- 特許番号
- US06953785B2
反応ノート
読み込み中…