2,4-Dichloropyrimidine → N-(1-pyridin-4-ylethyl)formamide

HRID 967468ノート

反応式

HRID 967468 の反応式
C(O)(=O)C.[NH:5]1[CH2:10][CH2:9][CH:8]([CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH2:7][CH2:6]1.ClC1N=C(Cl)C=CN=1.C(N(C(C)C)C(C)C)C>C(O)C>[N:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:13][CH:14]=[O:15])[CH3:12])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 775312,4-DichloropyrimidineHCID 81531DiisopropylethylamineHCID 86599800HCID 86599800、化合物

生成物 1

HCID 2771720N-(1-pyridin-4-ylethyl)formamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N-(1-Piperidin-4-yl-ethyl)-formamide; compound with acetic acid (350 mg, 1.61 mmol), 2,4-dichloro-pyrimidine (265 mg, 1.78 mmol) and ethyl-diisopropyl-amine (848 mg, 6.56 mmol) in 20 ml of ethanol were heated under reflux for 5 hours. The mixture was evaporated and the residue dissolved in water and extracted with ethyl acetate. The organic layer was dried with MgSO4 and evaporated.

後処理

  1. temperatureunder reflux for 5 hours
  2. customThe mixture was evaporated
  3. dissolutionthe residue dissolved in water
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried with MgSO4
  6. customevaporated

出典と根拠

ORDレコード
ord-35dac77553444a7fa1206542e86ca4d8
出典データセット
uspto-grants-2005_10
特許番号
US06953857B2

反応ノート

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