Sodium Hydroxide → 4-(4-Carbamoylphenoxymethyl)piperidin-4-ol

HRID 967773ノート

反応式

HRID 967773 の反応式
[OH-:1].[Na+].C([N:10]1[CH2:15][CH2:14][C:13]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)([OH:16])[CH2:12][CH2:11]1)C1C=CC=CC=1>C(O)C>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([O:18][CH2:17][C:13]2([OH:16])[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1)(=[O:1])[NH2:26]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22291260HCID 22291260、化合物

生成物 1

HCID 222912804-(4-Carbamoylphenoxymethyl)piperidin-4-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4N sodium hydroxide (6.8 mL) was added to an ethanol solution (30 mL) of the compound (2.2 g) obtained in Step 3 of Example 4 and the mixture was heated under reflux for four and half hours. The solvent was removed under reduced pressure and to the residue was added water (30 mL), and the precipitate was collected by filtration.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for four and half hours
  3. customThe solvent was removed under reduced pressure and to the residue
  4. additionwas added water (30 mL)
  5. filtrationthe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-5276b2473bca4975ad5a3bbbfa9eaf93
出典データセット
uspto-grants-2005_10
特許番号
US06956046B2

反応ノート

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