Oxalyl chloride → 3-Morpholinobenzoyl chloride
反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[O:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=C([CH:19]=[CH:20][CH:21]=2)C(O)=O)[CH2:9][CH2:8]1>C(Cl)Cl.CN(C=O)C>[O:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[C:1]([CH:19]=[CH:20][CH:21]=2)[C:2]([Cl:4])=[O:3])[CH2:9][CH2:8]1参加物
5
実験手順
Oxalyl chloride (0.14 ml) was added to a solution of 3-morpholinobenzoic acid (0.28 g) in methylene chloride (10 ml) which contained DMF (2 drops). The reaction mixture was stirred for 18 hours at ambient temperature. The mixture was evaporated and azeotroped with toluene to give 3-morpholinobenzoyl chloride (0.3 g); Mass M+H 222.
後処理
- customThe mixture was evaporated
- customazeotroped with toluene
出典と根拠
- ORDレコード
- ord-5e02ade00c204f609630fe6d0e5dcf6c
- 出典データセット
- uspto-grants-2005_10
- 特許番号
- US06956037B2
反応ノート
読み込み中…