反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][CH:12]=[C:11]([CH:14]([OH:16])[CH3:15])[CH:10]=2)=[CH:5][CH:4]=1.FC(F)(F)[C:21]1[CH:26]=[CH:25]C(C2C(C=O)=CSC=2)=[CH:23][CH:22]=1.C1([Mg]Br)C=CC=CC=1>>[C:15]1([CH:14]([C:11]2[CH:10]=[C:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:17])([F:1])[F:18])=[CH:8][CH:7]=3)[S:13][CH:12]=2)[OH:16])[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=1参加物
4
実験手順
The title compound was prepared using a method analogous to that used for the preparation of 1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol (intermediate 126) using 4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde (intermediate 125) and phenyl magnesium bromide.
出典と根拠
- ORDレコード
- ord-2336788b038b41e689f66b799d3c2b1d
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07091237B2
関連ノート
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