HCID 22291207、化合物 → tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate

HRID 967923ノート

反応式

HRID 967923 の反応式
C([N:8]1[CH2:23][CH2:22][CH2:21][C:9]21[CH2:13][N:12]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][CH2:10]2)C1C=CC=CC=1>CO.[Pd]>[CH2:13]1[C:9]2([CH2:21][CH2:22][CH2:23][NH:8]2)[CH2:10][CH2:11][N:12]1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]

参加物

4

反応物 1

HCID 22291207HCID 22291207、化合物

生成物 1

HCID 22291199tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of t-butyl 6-benzyl-2,6-diazaspiro[4.4]nonane-2-carboxylate (1.70 g, 5.37 mmol) in methanol (30 mL) was mixed with 10% palladium on carbon (50 mg). The mixture was shaken under a hydrogen atmosphere (50 psi) in a Parr hydrogenation apparatus for 8 h and filtered through Celite. The filtrate was concentrated by rotary evaporation and high vacuum treatment, leaving 1.26 g of viscous, light brown oil (>100%), which was of sufficient purity to be used in the subsequent reaction.

後処理

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation and high vacuum treatment

出典と根拠

ORDレコード
ord-6ee79e1228bf4f389cf742d3eff3adde
出典データセット
uspto-grants-2005_10
特許番号
US06956042B2

反応ノート

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