Triethylamine → HCID 9854221、化合物

反応式

Cl.Cl.[CH2:3]([O:5][C:6](=[O:14])[C@H:7]([CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])[NH2:8])[CH3:4].C(N([CH2:20][CH3:21])CC)C.[C:22]([O:47]N1C(=O)CCC1=O)(=O)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]/[CH:36]=[CH:37]\[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45]>C(Cl)(Cl)Cl>[CH2:3]([O:5][C:6](=[O:14])[C@H:7]([CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:22](=[O:47])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]/[CH:36]=[CH:37]\[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:20][CH3:21])[NH:8][C:22](=[O:47])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]/[CH:36]=[CH:37]\[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH3:4]

参加物

実験手順

To a stirred suspension of L-lysine ethyl ester dihydrochloride (6 mmol, 1.4 g, commercially available) and triethylamine (36 mmol, 3.6 g) in chloroform (80 mL), succinimidyl nervonate (18 mmol, 8.4 g, prepared as described in Example 1) was added in portions at room temperature. Stirring was continued overnight and, after removal of the solvent under reduced pressure, the product was crystallised from ethanol:water (1:1), yielding the title compound.