Ammonium Chloride → HCID 178461804、化合物

HRID 968205ノート

反応式

HRID 968205 の反応式
[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([S:15]CC3C=CC=CC=3)=[N:6][C:5]=2[N:23]=1.[Na].[Cl-].[NH4+]>N>[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([SH:15])=[N:6][C:5]=2[N:23]=1

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 11857680(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

生成物 1

HCID 178461804HCID 178461804、化合物収率 29.7%

試薬・触媒・溶媒 1

HCID 222Ammonia溶媒

実験手順

A stirred solution of the product of step (a) (1 g) in liquid ammonia (20 ml) was treated portionwise with sodium until a permanent blue colour was obtained. The solution was treated with ammonium chloride to dissipate the blue colour, and allowed to evaporate. The residue was taken up in water, filtered and purified by reverse phase preparative HPLC on Xterra® C8 column, using 0 to 20% acetonitrile in water at 20 ml/min over 2 min to give the subtitled compound (0.22 g)

後処理

  1. customwas obtained
  2. customto evaporate
  3. filtrationfiltered
  4. custompurified by reverse phase preparative HPLC on Xterra® C8 column
  5. customover 2 min

出典と根拠

ORDレコード
ord-d5f34948f1bd451db8558f768d8b36c3
出典データセット
uspto-grants-2005_10
特許番号
US06958343B2

反応ノート

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