2-Amino-2-methyl-1-propanol → HCID 178454505、化合物

反応式

Br[C:2]1[N:10]=[C:9]([S:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[F:20])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([NH:21]C(=O)OCC)[NH:6]2.[NH2:27][C:28]([CH3:32])([CH3:31])[CH2:29][OH:30]>>[NH2:21][C:5]1[NH:6][C:7]2[C:3]([N:4]=1)=[C:2]([NH:27][C:28]([CH3:32])([CH3:31])[CH2:29][OH:30])[N:10]=[C:9]([S:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=1[F:20])[N:8]=2

参加物

反応物 2

HCID 118072-Amino-2-methyl-1-propanol

HCID 178473456Ethyl 6-bromo-2-[(2,3-difluorobenzyl)thio]-9H-purin-8-ylcarbamate

生成物 1

HCID 178454505HCID 178454505、化合物

実験手順

The titled compound was prepared from the product of example 5, step (e) (50 mg) and 2-amino-2-methyl-1-propanol (66 μl) using the method of example 5, step (f) and purified by preparative HPLC to yield a white solid.

後処理

custompurified by preparative HPLC
customto yield a white solid

出典と根拠

ORDレコード: ord-f4f7eacc037d42829aea207659d2abe2
出典データセット: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06958344B2

反応ノート

読み込み中…

参加物