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1,4-Dibromo-2-nitrobenzene → 4-Bromo-2-nitrobenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dibromo-2-nitrobenzene | HCID 77004 | — |
| 反応物 | HCID 178418546 | HCID 178418546 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 4-Bromo-2-nitrobenzonitrile | HCID 292535 | — |
反応手順
Stir the mixture of 1,4-dibromo-2-nitro-benzene (3.56 mmol) and CuCN (3.74 mmol) in DMA (4 ml) at 100° C. for 5 hours. Cool to room temperature, dilute with EtOAc, filter through celite, wash the organic layer with brine, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (4:1 hexanes/EtOAc) to give 4-bromo-2-nitro-benzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07304059B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-599c89686c76459493cd79765109dd75 |
| 出典メモ | uspto-grants-2007_12 |