反应详情

Stir the mixture of 1,4-dibromo-2-nitro-benzene (3.56 mmol) and CuCN (3.74 mmol) in DMA (4 ml) at 100° C. for 5 hours. Cool to room temperature, dilute with EtOAc, filter through celite, wash the organic layer with brine, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (4:1 hexanes/EtOAc) to give 4-bromo-2-nitro-benzonitrile.

1. filtrationfilter through celite
2. washwash the organic layer with brine
3. dry with materialdry over Na2SO4
4. concentrationconcentrate under vacuum
5. customPurify the residue by flash chromatography (4:1 hexanes/EtOAc)