Nitric Acid → 2-(4-Methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine
反応式
[C:1]1([CH3:17])[CH:6]=[CH:5][C:4]([C:7]2[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:3][CH:2]=1.[N+:18]([O-])([OH:20])=[O:19]>OS(O)(=O)=O>[CH3:17][C:1]1[CH:2]=[CH:3][C:4]([C:7]2[C:12]([C:13]([F:16])([F:14])[F:15])=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:5][C:6]=1[N+:18]([O-:20])=[O:19]参加物
4
実験手順
To a solution of 2-p-tolyl-3-trifluoromethyl-pyridine (8.4 mmol) in H2SO4 (6 mL) cautiously add fuming HNO3 (2 ml). Stir the mixture for 60 minutes at room temperature. Pour the mixture onto ice-water (30 mL), extract with EtOAc, neutralize with 1 N NaOH, dry over Na2SO4, and concentrate under vacuum to obtain 2-(4-methyl-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine.
後処理
- additionPour the mixture onto ice-water (30 mL)
- extractionextract with EtOAc
- dry with materialdry over Na2SO4
- concentrationconcentrate under vacuum
出典と根拠
- ORDレコード
- ord-1ddb673d88434cb2a0efb4dc17563a7f
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07304059B2
反応ノート
読み込み中…