Triethylamine → 2H-Perfluoroisopropyl 2-fluoroacrylate
反応式
[F:1][C:2](=[CH2:6])[C:3](Cl)=[O:4].[F:7][C:8]([F:16])([F:15])[CH:9]([OH:14])[C:10]([F:13])([F:12])[F:11].C(N(CC)CC)C>O>[F:1][C:2](=[CH2:6])[C:3]([O:14][CH:9]([C:10]([F:13])([F:12])[F:11])[C:8]([F:16])([F:15])[F:7])=[O:4]参加物
5
実験手順
12 g of 2-fluoroacryloyl chloride and 27 g of 1,1,1,3,3,3-hexafluoro-2-propanol were introduced into a round-bottomed flask placed in an ice bath. 16 g of triethylamine were added portionwise to the reaction mixture. After reacting for an additional 3 h, approximately 70 ml of water were added. The aqueous and organic phases were subsequently separated and the organic phase was analysed by GC. The conversion of the 1,1,1,3,3,3-hexafluoroisopropanol was 68%. The yield of ester, based on the amount of 2-fluoroacrylic acid employed in the first stage, was 66%.
後処理
- customplaced in an ice bath
- customThe aqueous and organic phases were subsequently separated
出典と根拠
- ORDレコード
- ord-c02449b42c1f45c4ba80c9b51c107c04
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07304191B2
反応ノート
読み込み中…