HCID 69459677、化合物 → HCID 69459918、化合物

HRID 969465ノート

反応式

HRID 969465 の反応式
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]([OH:35])[CH2:21][NH:22][C:23]([CH3:34])([CH3:33])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[F:32])=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)C1C=CC=CC=1>CO.[Pd]>[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[CH2:24][C:23]([NH:22][CH2:21][CH:20]([C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[C:18]2[C:13]=1[CH2:14][CH2:15][C:16](=[O:19])[NH:17]2)[OH:35])([CH3:33])[CH3:34]

参加物

4

反応物 1

HCID 69459677HCID 69459677、化合物

生成物 1

HCID 69459918HCID 69459918、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 220 mg (0.5 mmol) 8-benzyloxy-5-{2-[2-(2,4-difluoro-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-1H-quinolin-2-one in 10 mL methanol is hydrogenated in the presence of palladium on charcoal at ambient temperature and normal pressure. Then the catalyst is separated off, the filtrate is evaporated down and the residue is chromatographed (reverse phase; water/acetonitrile gradient).

後処理

  1. customThen the catalyst is separated off
  2. customthe filtrate is evaporated down
  3. customthe residue is chromatographed (reverse phase; water/acetonitrile gradient)

出典と根拠

ORDレコード
ord-eefb1c3489244838afd841f0be854723
出典データセット
uspto-grants-2007_12
特許番号
US07307076B2

反応ノート

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