2,4-Dichlorobenzylamine → N-(2,4-dichlorobenzyl)-3-oxo-6-[4-(benzyloxy)phenyl]-2,3-dihydropyridazine-4-carboxamide

HRID 970188

反応式

[O:1]=[C:2]1[C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13](OCC)=O)=[O:9])=[CH:6][C:5]([C:18]2[CH:23]=[CH:22]N=[CH:20][CH:19]=2)=[N:4][NH:3]1.[CH2:24]([O:31][C:32]1C=CC(C2CC(C(O)=O)C(=O)NN=2)=CC=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.ON1C2C=CC=CC=2N=N1.[Cl:58][C:59]1[CH:66]=[C:65]([Cl:67])C=C[C:60]=1CN.C(N(CC)C(C)C)(C)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1>CN(C)C=O>[Cl:67][C:65]1[CH:66]=[C:59]([Cl:58])[CH:60]=[CH:13][C:12]=1[CH2:11][NH:10][C:8]([C:7]1[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:18]2[CH:19]=[CH:20][C:32]([O:31][CH2:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:22][CH:23]=2)[CH:6]=1)=[O:9]

参加物

実験手順

Working as in example 13 for the preparation of ethyl 3-[(3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carbonyl)amino]propionate, but starting with 1 g of 6-[4-(benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid, 100 cm3 of N,N-dimethylformamide, 0.523 g of 1-hydroxybenzotriazole, 0.56 cm3 of 2,4-dichlorobenzylamine, 1.1 cm3 of N,N-diisopropylethylamine and 1.47 g of O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 1.02 g of N-(2,4-dichlorobenzyl)-3-oxo-6-[4-(benzyloxy)phenyl]-2,3-dihydropyridazine-4-carboxamide were obtained in the form of a yellow solid melting at 225° C.

出典と根拠

ORDレコード: ord-62f97621def3430e87e745a8348bd32a
出典データセット: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07309701B2

反応式

参加物

反応物 6

生成物 1

試薬・触媒・溶媒 1

実験手順

出典と根拠

関連ノート