Piperacillin → Piperacillin 2-acetamido-2-deoxy-N-(1-amino-(R/S)-dodecoyl)-beta-D-gluco-pyranosylamine

HRID 970294

反応式

HRID 970294 の反応式
[CH3:1][CH2:2][N:3]1[C:9](=[O:10])[C:7](=[O:8])[N:6]([C:11]([NH:13][C@@H:14]([C:21]([NH:23][C@@H:24]2[C:27](=[O:28])[N:26]3[C@@H:29]([C:34]([OH:36])=[O:35])[C:30]([CH3:33])([CH3:32])[S:31][C@H:25]23)=[O:22])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:12])[CH2:5][CH2:4]1.[C:37]([NH:40][C@@H:41]1[C@@H:46]([OH:47])[C@H:45]([OH:48])[C@@H:44]([CH2:49][OH:50])[O:43][C@H:42]1[NH:51][CH:52]([CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH3:65])[C:53]([NH2:55])=[O:54])(=[O:39])[CH3:38]>C(O)(=O)C>[CH3:1][CH2:2][N:3]1[C:9](=[O:10])[C:7](=[O:8])[N:6]([C:11]([NH:13][C@@H:14]([C:21]([NH:23][C@@H:24]2[C:27](=[O:28])[N:26]3[C@@H:29]([C:34]([OH:36])=[O:35])[C:30]([CH3:32])([CH3:33])[S:31][C@H:25]23)=[O:22])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:5][CH2:4]1.[C:37]([NH:40][C@@H:41]1[C@@H:46]([OH:47])[C@H:45]([OH:48])[C@@H:44]([CH2:49][OH:50])[O:43][C@H:42]1[NH:51][CH:52]([CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH3:65])[C:53]([NH2:55])=[O:54])(=[O:39])[CH3:38]

参加物

4

反応物 2

HCID 43672PiperacillinHCID 1317267252-acetamido-2-deoxy-N-(1-amino-(R/S)-dodecoyl)-beta-D-glucopyranosylamine

生成物 1

HCID 131726724Piperacillin 2-acetamido-2-deoxy-N-(1-amino-(R/S)-dodecoyl)-beta-D-gluco-pyranosylamine収率 97%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Piperacillin (2.00 g, 3.87 mmol) and 2-acetamido-2-deoxy-N-(1-amino-(R/S)-dodecoyl)-β-D-glucopyranosylamine (32) (1.61 g, 3.87 mmol) were dissolved in 95% acetic acid. Once fully dissolved, the solution was filtered and lyophilised to give (35) as a white solid (3.50 g, 97%).

後処理

  1. dissolutionOnce fully dissolved
  2. filtrationthe solution was filtered

出典と根拠

ORDレコード
ord-687e629e145f4b0997f44d0314ac4f67
出典データセット
uspto-grants-2007_12
特許番号
US07312194B2

関連ノート

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