Tert-butyl n-[1-(azidomethyl)undecyl]-carbamate → t-butyl N-(1-aminododecan-2-yl) carbamate

HRID 970302ノート

反応式

HRID 970302 の反応式
[N:1]([CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[N+]=[N-]>[Pd].CO>[NH2:1][CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

4

反応物 1

HCID 91612995Tert-butyl n-[1-(azidomethyl)undecyl]-carbamate

生成物 1

HCID 87843007t-butyl N-(1-aminododecan-2-yl) carbamate収率 92.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Palladium catalyst (10% on carbon, 10.0 mg) was added in one portion to a solution of tert-butyl N-[1-(azidomethyl)undecyl]-carbamate 63 (100 mg, 0.282 mmol) in abs. methanol (5 ml) under a hydrogen atmosphere. The solution was allowed to stir for 12 hours. The catalyst was subsequently filtered off, and the solvent evaporated to give 64 (78 mg, 84%).

後処理

  1. filtrationThe catalyst was subsequently filtered off
  2. customthe solvent evaporated

出典と根拠

ORDレコード
ord-2d0eb11366644590a0c8c9fd1e987b95
出典データセット
uspto-grants-2007_12
特許番号
US07312194B2

反応ノート

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