Quinuclidine → 1-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

HRID 970307ノート

反応式

HRID 970307 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][N:5]=[C:6]=[S:7].[N:8]12[CH2:15][CH2:14][CH:11]([CH2:12][CH2:13]1)[CH2:10][CH2:9]2>C(#N)C>[Br-:1].[N:5]([CH2:4][CH2:3][CH2:2][N+:8]12[CH2:15][CH2:14][CH:11]([CH2:12][CH2:13]1)[CH2:10][CH2:9]2)=[C:6]=[S:7]

参加物

4

反応物 2

HCID 7527QuinuclidineHCID 1377143-Bromopropyl isothiocyanate

生成物 1

HCID 231542151-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
50 °C

実験手順

To a solution of 55 mg of 3-bromopropyl isothiocyanate in 1 ml of acetonitrile was added 33 mg of quinuclidine, and the mixture was heated at 50° C for 19 hours. The reaction solution was concentrated and the residue was washed 3 times with 1 ml of ether to obtain the title compound.

後処理

  1. concentrationThe reaction solution was concentrated
  2. washthe residue was washed 3 times with 1 ml of ether

出典と根拠

ORDレコード
ord-fdf8a04abea84e4085a51cac43632810
出典データセット
uspto-grants-2007_12
特許番号
US07312208B2

反応ノート

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