HCID 21054729、化合物 → 1-Boc-4-aMino-4-trifluoroMethylpiperidine

HRID 970374ノート

反応式

HRID 970374 の反応式
C(OC([NH:11][C:12]1([C:25]([F:28])([F:27])[F:26])[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]1)=O)C1C=CC=CC=1>[Pd].CCO>[NH2:11][C:12]1([C:25]([F:28])([F:26])[F:27])[CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:22])[CH3:23])=[O:19])[CH2:16][CH2:17]1

参加物

4

反応物 1

HCID 21054729HCID 21054729、化合物

生成物 1

HCID 210547281-Boc-4-aMino-4-trifluoroMethylpiperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

10% Palladium on carbon (a catalytic amount) is added carefully to a solution of 4-(benzyloxycarbonyl)amino-1-(tert-butoxycarbonyl)-4-(trifluoromethyl)piperidine (3d) (1 equiv.) in EtOH, and the mixture is shaken under H2 (50 psi) on a Parr apparatus. When the reaction is complete, the solution is filtered through a pad of celite®, and the filter pad is washed with EtOH. The filtrate is concentrated to yield the title compound.

後処理

  1. filtrationthe solution is filtered through a pad of celite®
  2. washthe filter pad is washed with EtOH
  3. concentrationThe filtrate is concentrated

出典と根拠

ORDレコード
ord-bc4b36888cab4c0e86042163707bc827
出典データセット
uspto-grants-2007_12
特許番号
US07312212B2

反応ノート

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