Sodium Carbonate → 3-Chloro-6-methoxyquinolin-4-ol
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[OH:13].[Cl:14]N1C(=O)CCC1=O.P(Br)(Br)Br.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C.CN(C=O)C.O>[Cl:14][C:7]1[CH:8]=[N:9][C:10]2[C:5]([C:6]=1[OH:13])=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2参加物
8
実験手順
3-Chloro-6-methoxy-quinolin-4-ol was prepared as described in WO 02\40474 by heating 6-methoxy-quinolin-4-ol with N-chloro-succinimide in acetic acid at 65° C. (96%) and (11 g) in dry DMF (80 mL) cooled in ice, was treated with phosphorus tribromide (15.6 g) and stirred at room temperature for 3.5 h. It was treated with iced-water, basified with sodium carbonate solution, and the solid collected and washed with water and dried in vacuo to afford a yellow solid (13.2 g).
後処理
- temperaturecooled in ice
- customthe solid collected
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-b44ab9cf352e4e3bb013a77884db895d
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07312212B2
反応ノート
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