Malononitrile → ST050948

HRID 970392

反応式

HRID 970392 の反応式
C(N(CC)CC)C.O[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[C:16](#[N:20])[CH2:17][C:18]#[N:19]>CO>[NH2:20][C:16]1[O:15][C:10]2[CH2:11][CH2:12][CH2:13][CH2:14][C:9]=2[C:17]=1[C:18]#[N:19]

参加物

5

反応物 3

HCID 8010MalononitrileHCID 8471TriethylamineHCID 10785Cyclohexanone, 2-hydroxy-

生成物 1

HCID 673083ST050948収率 81.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.1 4.8 ml of triethylamine are added dropwise to a solution of 11.0 g of 2-hydroxycyclohexanone and 9.6 g of malononitrile in 25 ml of methanol, and the mixture is stirred at room temperature for a further 4 hours. The crystals which deposit are separated off and washed with methanol, giving 12.8 g of 2-amino-4,5,6,7-tetrahydrobenzofuran-3-carbonitrile (“BA”), m.p. 179°.

後処理

  1. customThe crystals which deposit are separated off
  2. washwashed with methanol

出典と根拠

ORDレコード
ord-4a7c5bb2c2bb4edc850a4550919d89b8
出典データセット
uspto-grants-2007_12
特許番号
US07312224B2

関連ノート

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