HCID 23509661、化合物 → 4-(4-Fluorobenzyl)-1-(3-pyrrolidinylmethyl)piperidine

HRID 970404ノート

反応式

HRID 970404 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]3[CH2:20][CH2:19][N:18](C(OCC4C=CC=CC=4)=O)[CH2:17]3)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[H][H]>[Pd].CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]3[CH2:20][CH2:19][NH:18][CH2:17]3)[CH2:11][CH2:10]2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 23509661HCID 23509661、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 541749794-(4-Fluorobenzyl)-1-(3-pyrrolidinylmethyl)piperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a stirring solution of 3-[4-(4-flourophenylmethyl)piperidinomethyl]-N-(benzyloxycarbonyl)-pyrrolidine (600 mg, 1.47 mmol) and 5% palladium on carbon (60 mg, Aldrich) in MeOH (50 mL) was added 50 psi of hydrogen. The reaction was stirred for 14 h. The reaction was filtered and the filtrate was conc. in vacuo to a colorless oil. The oil can be used without further purification. MS (ESI) 277 (M+H).

後処理

  1. filtrationThe reaction was filtered
  2. customThe oil can be used without further purification

出典と根拠

ORDレコード
ord-f8229e0edba541a8a7dd0fb2db3cc1e7
出典データセット
uspto-grants-2007_12
特許番号
US07312222B2

反応ノート

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