7-Nitroquinoline → 7-Aminoquinoline
反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-])=O>[Pd].CO>[N:11]1[C:12]2[C:7](=[CH:6][CH:5]=[C:4]([NH2:1])[CH:13]=2)[CH:8]=[CH:9][CH:10]=1参加物
4
実験手順
A mixture of 7-nitroquinoline (0.30 g, 0.0017 mol; Specs, Inc.), 10% Pd—C (50 mg), and MeOH (20 mL) was stirred under H2 (1 atm) for 2 h. The mixture was filtered and the filtrate was concentrated to give a yellow solid (235 mg, 95%). LC-MS: 0.33 min, 145.1 (M+1).
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-dbd05ba4407b4126811b27d90fa44957
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07312233B2
反応ノート
読み込み中…